Aquaporin-2 Inhibitors: Fishing in the Chemical Pool
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چکیده
منابع مشابه
Aquaporin-2 inhibitors: fishing in the chemical pool.
The critical contribution of aquaporin-2 (AQP) to water homeostasis in mammals is highlighted by the severe concentrating defects seen in humans with mutations in the AQP2 gene and in mice that are AQP2 null or have loss-of-function mutations in AQP2.1,2 The role of the antidiuretic hormone vasopressin and its receptor, V2R, in the signaling cascade that leads to membrane accumulation of AQP2 i...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2013
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2013030243